In the last couple of years, numerous controlled studies about the prophylactic effectiveness of Botulinum Toxin A in the treatment of migraine have been published. The group of authors working with the American neurologist Silberstein was able to prove a significant reduction in the frequency of migraine attacks, a reduction of the average intensity of pain, a reduction of days with vomiting, as well as a reduction of days with acute medication. Further studies produced similar results. Significant side effects were not described and the effects of singular injection lasted for more than 3 months. At present, several large international multicentre studies assessing the effect of Botulinum Toxin A on migraine are taking place. In addition, numerous smaller studies which show an effect have already been published.

Botox is not yet licensed for treating migraines in Germany and is therefore not funded by the German health insurance providers. However, since it has already been licensed in the US and the UK, we can expect it to be licensed in Germany for treatment of migraines soon.

One unit of botox (sufficient for one treatment cycle) costs around 350 € plus medical costs for the doctor. It is very important that the treatment is done by an experienced doctor (neurologist). Treatment is only successful if the right injection sites are chosen.

Botox is usually injected in the area of the head, the temples, forehead, neck and shoulders. Before the injections, a thorough examination by an experienced specialist is necessary. Wrongly placed injections will have no effect for the treatment of migraine.