Lack of appetite, nausea and vomiting can be accompanying effects of migraine attacks. Additionally, the muscles of the stomach are often restricted in their mobility and thus the movement of the chyme.
So called antiemetics (remedies against nausea and vomiting) are supposed to correct these dysfunctions during a migraine attack. The paralysis of the stomach during the migraine attack restricts the pain medication from being properly transported to the intestines.
Consequences: The expected results do not occur. This is why you should take an antiemetic (Metoclopramid or Domperidon) 15 minutes before taking the migraine medication. During this time period the mobility of the stomach returns to normal and the migraine medication can develop its effectiveness.
Effect: Normalization of the gastrointestinal tract, relief from nausea and vomiting.
Precautionary measures: Precautions should be taken with people with kidney diseases and children under the age of 14. Antiemetics are not allowed to be taken with intestinal obstructions or intestinal bleeding, epilepsy, movement disorder, certain hormone building tumors and in combination with MAO inhibitors (gastric acid inhibiting substances)
Possible side effects: Rarely, fatigue, dizziness or diarrhea occur. Very rarely, movement disorder in the form of uncontrollable movements of the mouth, throat or tongue cramps, head turning, problems swallowing or eye turning. In these cases an overdose exists and you should call a doctor. By giving an antidote these unpleasent but otherwise harmless side effects can be cured quickly.